Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

BACKGROUND: The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol(™)) in cats. METHODS: Six healthy cats (4.9 ± 0.7 kg) were included in a prospective, randomized, blin...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Doodnaught, Graeme M., Monteiro, Beatriz P., Benito, Javier, Edge, Daniel, Beaudry, Francis, Pelligand, Ludovic, Steagall, Paulo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405979/
https://ncbi.nlm.nih.gov/pubmed/28445495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176443
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