Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function

In Wfs1(−/−)A(y)/a islets, in association with endoplasmic reticulum (ER) stress, D-site-binding protein (Dbp) expression decreased and Nuclear Factor IL-3 (Nfil3)/E4 Promoter-binding protein 4 (E4bp4) expression increased, leading to reduced DBP transcriptional activity. Similar alterations were ob...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Ohta, Yasuharu, Taguchi, Akihiko, Matsumura, Takuro, Nakabayashi, Hiroko, Akiyama, Masaru, Yamamoto, Kaoru, Fujimoto, Ruriko, Suetomi, Risa, Yanai, Akie, Shinoda, Koh, Tanizawa, Yukio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405175/
https://ncbi.nlm.nih.gov/pubmed/28389215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.03.040
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