Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

BACKGROUND: Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality i...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Anderson, Letícia, Gomes, Monete Rajão, daSilva, Lucas Ferreira, Pereira, Adriana da Silva Andrade, Mourão, Marina M., Romier, Christophe, Pierce, Raymond, Verjovski-Almeida, Sergio
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404884/
https://ncbi.nlm.nih.gov/pubmed/28406899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005539
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky