Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome

Mycobacterium tuberculosis is responsible for the greatest number of deaths worldwide due to a bacterial agent. We recently identified bortezomib (Velcade; compound 1) as a promising antituberculosis (anti-TB) compound. We showed that compound 1 inhibits the mycobacterial caseinolytic proteases P1 a...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Moreira, Wilfried, Santhanakrishnan, Sridhar, Ngan, Grace J. Y., Low, Choon Bing, Sangthongpitag, Kanda, Poulsen, Anders, Dymock, Brian W., Dick, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404560/
https://ncbi.nlm.nih.gov/pubmed/28193668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02307-16
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