Overexpression of SmeDEF Efflux Pump Decreases Aminoglycoside Resistance in Stenotrophomonas maltophilia

The SmeDEF pump of Stenotrophomonas maltophilia is negatively regulated by SmeT. In this study, strains KJΔT (smeT deletion mutant) and KJT-D(m) (mutant with a defective SmeT-binding site) showed increased resistance to chloramphenicol/nalidixic acid/macrolides and susceptibility to aminoglycoside....

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Huang, Yi-Wei, Lin, Cheng-Wen, Ning, Hsiao-Chen, Lin, Yi-Tsung, Chang, Yi-Chih, Yang, Tsuey-Ching
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404512/
https://ncbi.nlm.nih.gov/pubmed/28193669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02685-16
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