The Association of CYP19A1 Variation with Circulating Estradiol and Aromatase Inhibitor Outcome: Can CYP19A1 Variants Be Used to Predict Treatment Efficacy?

After menopause, estradiol is primarily synthesized in peripheral tissues by the enzyme aromatase, encoded by CYP19A1. CYP19A1 variation associates with circulating estradiol in postmenopausal women and this variation is best represented by the intronic variant rs727479. This variation appears to ha...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Glubb, Dylan M., O'Mara, Tracy A., Shamsani, Jannah, Spurdle, Amanda B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403944/
https://ncbi.nlm.nih.gov/pubmed/28487654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00218
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