The Association of CYP19A1 Variation with Circulating Estradiol and Aromatase Inhibitor Outcome: Can CYP19A1 Variants Be Used to Predict Treatment Efficacy?

After menopause, estradiol is primarily synthesized in peripheral tissues by the enzyme aromatase, encoded by CYP19A1. CYP19A1 variation associates with circulating estradiol in postmenopausal women and this variation is best represented by the intronic variant rs727479. This variation appears to ha...

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Опубликовано в: :Front Pharmacol
Главные авторы: Glubb, Dylan M., O'Mara, Tracy A., Shamsani, Jannah, Spurdle, Amanda B.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403944/
https://ncbi.nlm.nih.gov/pubmed/28487654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00218
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