Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci

The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Rolo, Joana, Worning, Peder, Boye Nielsen, Jesper, Sobral, Rita, Bowden, Rory, Bouchami, Ons, Damborg, Peter, Guardabassi, Luca, Perreten, Vincent, Westh, Henrik, Tomasz, Alexander, de Lencastre, Hermínia, Miragaia, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402963/
https://ncbi.nlm.nih.gov/pubmed/28394942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006674
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