Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

Most genetic association signals for type 2 diabetes risk are located in non-coding regions of the genome, hindering translation into molecular mechanisms. Physiological studies have shown a majority of disease-associated variants to exert their effects through pancreatic islet dysfunction. Systemat...

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Bibliographic Details
Published in:Diabetes
Main Authors: Thomsen, Soren K, Ceroni, Alessandro, van de Bunt, Martijn, Burrows, Carla, Barrett, Amy, Scharfmann, Raphael, Ebner, Daniel, McCarthy, Mark I, Gloyn, Anna L
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402869/
https://ncbi.nlm.nih.gov/pubmed/27554474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0361
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