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Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis

Advancing age is an independent risk factor for cardiovascular disease. Matrix metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left ventricle (LV) with age. The present study investigated the effect of MMP-9 overexpression in macrophages on cardiac aging. We comp...

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Опубликовано в: :Am J Physiol Heart Circ Physiol
Главные авторы: Toba, Hiroe, Cannon, Presley L., Yabluchanskiy, Andriy, Iyer, Rugmani Padmanabhan, D’Armiento, Jeanine, Lindsey, Merry L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402013/
https://ncbi.nlm.nih.gov/pubmed/28011588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00633.2016
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