Kvβ1.1 (AKR6A8) senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity

The present study investigates the physiological role of Kvβ1 subunit for sensing pyridine nucleotide (NADH/NAD+) changes in the heart. We used Kvβ1.1 knockout (KO) or wild-type (WT) mice and established that Kvβ1.1 preferentially binds with Kv4.2 and senses the pyridine nucleotide changes in the he...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Tur, Jared, Chapalamadugu, Kalyan C., Katnik, Christopher, Cuevas, Javier, Bhatnagar, Aruni, Tipparaju, Srinivas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402009/
https://ncbi.nlm.nih.gov/pubmed/27986658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00281.2016
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