Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT), is a cytozyme which regulates intracellular NAD levels and cellular redox state, regulates histone deacetylases...

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Udgivet i:Circulation
Main Authors: Chen, Jiwang, Sysol, Justin R., Singla, Sunit, Zhao, Shuangping, Yamamura, Aya, Valdez-Jasso, Daniela, Abbasi, Taimur, Shioura, Krystyna M., Sahni, Sakshi, Reddy, Vamsi, Sridhar, Arvind, Gao, Hui, Torres, Jaime, Camp, Sara M., Tang, Haiyang, Ye, Shui Qing, Comhair, Suzy, Dweik, Raed, Hassoun, Paul, Yuan, Jason X.-J, Garcia, Joe G.N., Machado, Roberto F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400780/
https://ncbi.nlm.nih.gov/pubmed/28202489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024557
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