Functional RNAs: combined assembly and packaging in VLPs

We describe here a one pot RNA production, packaging and delivery system based on bacteriophage Qβ. We demonstrate a method for production of a novel RNAi scaffold, packaged within Qβ virus-like particles (VLPs). The RNAi scaffold is a general utility chimera that contains a functional RNA duplex wi...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Fang, Po-Yu, Gómez Ramos, Lizzette M., Holguin, Stefany Y., Hsiao, Chiaolong, Bowman, Jessica C., Yang, Hung-Wei, Williams, Loren Dean
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399791/
https://ncbi.nlm.nih.gov/pubmed/27903913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1154
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