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Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases

Surface expression of chemokine receptor CXCR4 is downregulated by missing-in-metastasis protein (MIM; also known as MTSS1), a member of the inverse BAR (I-BAR)-domain protein family that recognizes and generates membranes with negative curvature. Yet, the mechanism for the regulation is unknown. He...

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Publicat a:J Cell Sci
Autors principals: Li, Lushen, Baxter, Shaneen S., Gu, Ning, Ji, Min, Zhan, Xi
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399787/
https://ncbi.nlm.nih.gov/pubmed/28264927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.198937
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