Th1 differentiation drives the accumulation of intravascular, non-protective CD4 T cells during tuberculosis

Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1 polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find IL-12/23p40 promotes Th1...

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Detalles Bibliográficos
Publicado en:Cell Rep
Main Authors: Sallin, Michelle A., Sakai, Shunsuke, Kauffman, Keith D., Young, Howard A., Zhu, Jinfang, Barber, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399512/
https://ncbi.nlm.nih.gov/pubmed/28355562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.007
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