Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation–Strain-Promoted (4 + 2) Cycloaddition

[Image: see text] Genetically encoded tyrosine (Y-tag) can be utilized as a latent anchor for inducible and site-selective conjugation. Upon oxidation of tyrosine with mushroom tyrosinase, strain-promoted cycloaddition (SPOCQ) of the resulting 1,2-quinone with various bicyclo[6.1.0]nonyne (BCN) deri...

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Détails bibliographiques
Publié dans:Bioconjug Chem
Auteurs principaux: Bruins, Jorick J., Westphal, Adrie H., Albada, Bauke, Wagner, Koen, Bartels, Lina, Spits, Hergen, van Berkel, Willem J. H., van Delft, Floris L.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399473/
https://ncbi.nlm.nih.gov/pubmed/28263569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00046
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