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The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

Neutrophil granulocytes are innate effector cells of the first line of defense against pyogenic bacteria. Neutrophil lifespan is short, is prolonged by pro-inflammatory stimuli, controls functionality of the cells and can determine tissue damage. Experimental analysis of primary neutrophils is diffi...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Vier, J, Groth, M, Sochalska, M, Kirschnek, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399193/
https://ncbi.nlm.nih.gov/pubmed/26890142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.23
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