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Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesi...
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| Veröffentlicht in: | Intensive Care Med Exp |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399012/ https://ncbi.nlm.nih.gov/pubmed/28429311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-017-0137-2 |
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