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Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesi...

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Detalhes bibliográficos
Publicado no:Intensive Care Med Exp
Main Authors: Jeger, Victor, Arrigo, Mattia, Hildenbrand, Florian F., Müller, Daniel, Jirkof, Paulin, Hauffe, Till, Seifert, Burkhardt, Arras, Margarete, Spahn, Donat R., Bettex, Dominique, Rudiger, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399012/
https://ncbi.nlm.nih.gov/pubmed/28429311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-017-0137-2
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