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Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on the Membrane Dipole Electric Field Using Vibrational Stark Effect Spectroscopy Coupled With Molecular Dynamics Simulations

Biological membranes are heterogeneous structures with complex electrostatic profiles arising from lipids, sterols, membrane proteins, and water molecules. We investigated the effect of cholesterol and its derivative 6-ketocholestanol (6-kc) on membrane electrostatics by directly measuring the dipol...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Shrestha, Rebika, Anderson, Cari M., Cardenas, Alfredo E., Elber, Ron, Webb, Lauren J.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398937/
https://ncbi.nlm.nih.gov/pubmed/28071910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b09007
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