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Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation

Gonad morphogenesis relies on the correct spatiotemporal expression of a number of genes that together fulfill the differentiation of the bipotential gonad into testes or ovaries. As such, the transcription factors WT1 and GATA4 are pivotal for proper gonadal development. Here we address the contrib...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Rudigier, Lucas J., Dame, Christof, Scholz, Holger, Kirschner, Karin M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398674/
https://ncbi.nlm.nih.gov/pubmed/28426816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176296
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