Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women

BACKGROUND: Variants of unknown significance (VUSs) have been identified in BRCA1 and BRCA2 and account for the majority of all identified sequence alterations. Notably, VUSs occur disproportionately in people of African descent hampering breast cancer (BCa) management and prevention efforts in the...

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Pubblicato in:Ethn Dis
Autori principali: Ricks-Santi, Luisel, McDonald, J. Tyson, Gold, Bert, Dean, Michael, Thompson, Nicole, Abbas, Muneer, Wilson, Bradford, Kanaan, Yasmine, Naab, Tammey J., Dunston, Georgia
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Society on Hypertension in Blacks 2017
Soggetti:
Original Report: Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398176/
https://ncbi.nlm.nih.gov/pubmed/28439188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18865/ed.27.2.169
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