Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women

BACKGROUND: Variants of unknown significance (VUSs) have been identified in BRCA1 and BRCA2 and account for the majority of all identified sequence alterations. Notably, VUSs occur disproportionately in people of African descent hampering breast cancer (BCa) management and prevention efforts in the...

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發表在:Ethn Dis
Main Authors: Ricks-Santi, Luisel, McDonald, J. Tyson, Gold, Bert, Dean, Michael, Thompson, Nicole, Abbas, Muneer, Wilson, Bradford, Kanaan, Yasmine, Naab, Tammey J., Dunston, Georgia
格式: Artigo
語言:Inglês
出版: International Society on Hypertension in Blacks 2017
主題:
Original Report: Cancer
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398176/
https://ncbi.nlm.nih.gov/pubmed/28439188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18865/ed.27.2.169
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