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AFIR: A Dimensionless Potency Metric for Characterizing the Activity of Monoclonal Antibodies
For monoclonal antibody (mAb) drugs, soluble targets may accumulate several thousand fold after binding to the drug. Time course data of mAb and total target is often collected and, although free target is more closely related to clinical effect, it is difficult to measure. Therefore, mathematical m...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5397564/ https://ncbi.nlm.nih.gov/pubmed/28375563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12169 |
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