Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

The two main drivers of Alzheimer's disease (AD), amyloid-β (Aβ) and hyperphosphorylated Tau (p-Tau) oligomers, cooperatively accelerate AD progression, but a hot debate is still ongoing about which of the two appears first. Here we present preliminary evidence showing that Tau and p-Tau are ex...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Chiarini, Anna, Armato, Ubaldo, Gardenal, Emanuela, Gui, Li, Dal Prà, Ilaria
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397492/
https://ncbi.nlm.nih.gov/pubmed/28473749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00217
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