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Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event
Life originated in an anoxic, Fe(2+)-rich environment. We hypothesize that on early Earth, Fe(2+) was a ubiquitous cofactor for nucleic acids, with roles in RNA folding and catalysis as well as in processing of nucleic acids by protein enzymes. In this model, Mg(2+) replaced Fe(2+) as the primary co...
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| Published in: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5397171/ https://ncbi.nlm.nih.gov/pubmed/28334877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx171 |
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