A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway

BACKGROUND: Pancreatic cancer is one of the most aggressive and intractable malignant tumors, and most deaths from pancreatic cancer are related to metastases. It has been demonstrated in vitro that overexpression of programmed death-ligand 1 (PD-L1) correlates with a lack of phosphatase and tensin...

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Dettagli Bibliografici
Pubblicato in:Onco Targets Ther
Autori principali: Zhao, Lei, Li, Cheng, Liu, Fei, Zhao, Yonghong, Liu, Jun, Hua, Ye, Liu, Jinyang, Huang, Jiapeng, Ge, Chunlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396961/
https://ncbi.nlm.nih.gov/pubmed/28442920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S130481
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