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Absence of non-histone protein complexes at natural chromosomal pause sites results in reduced replication pausing in aging yeast cells

There is substantial evidence that genomic instability increases during aging. Replication pausing (and stalling) at difficult-to-replicate chromosomal sites may induce genomic instability. Interestingly, in aging yeast cells we observed reduced replication pausing at various natural replication pau...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Cabral, Marleny, Cheng, Xin, Singh, Sukhwinder, Ivessa, Andreas S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396545/
https://ncbi.nlm.nih.gov/pubmed/27829146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.050
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