Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

BACKGROUND. Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and...

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Published in:JCI Insight
Main Authors: Arlt, Wiebke, Lang, Katharina, Sitch, Alice J., Dietz, Anna S., Rhayem, Yara, Bancos, Irina, Feuchtinger, Annette, Chortis, Vasileios, Gilligan, Lorna C., Ludwig, Philippe, Riester, Anna, Asbach, Evelyn, Hughes, Beverly A., O’Neil, Donna M., Bidlingmaier, Martin, Tomlinson, Jeremy W., Hassan-Smith, Zaki K., Rees, D. Aled, Adolf, Christian, Hahner, Stefanie, Quinkler, Marcus, Dekkers, Tanja, Deinum, Jaap, Biehl, Michael, Keevil, Brian G., Shackleton, Cedric H.L., Deeks, Jonathan J., Walch, Axel K., Beuschlein, Felix, Reincke, Martin
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
Subjects:
Clinical Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396526/
https://ncbi.nlm.nih.gov/pubmed/28422753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93136
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