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An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a cytochrome‐dependent CYP450, and an aldehyde reductase convert farnesyl diphosphate (FDP) into dihydroartemisinic aldehyde (DHAA...
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| Publicado no: | Angew Chem Int Ed Engl |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5396139/ https://ncbi.nlm.nih.gov/pubmed/28294491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201609557 |
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