Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A

BACKGROUND: Non-small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor (EGFR) gene mutations (exon 19 deletion or exon 21 L858R) respond to EGFR tyrosine kinase inhibitors (EGFR-TKIs). The secondary T790 M mutation in exon 20 of the EGFR gene is the most common type of acqu...

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Publicado en:BMC Cancer
Autores principales: Chiba, Masato, Togashi, Yosuke, Bannno, Eri, Kobayashi, Yoshihisa, Nakamura, Yu, Hayashi, Hidetoshi, Terashima, Masato, De Velasco, Marco A., Sakai, Kazuko, Fujita, Yoshihiko, Mitsudomi, Tetsuya, Nishio, Kazuto
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395747/
https://ncbi.nlm.nih.gov/pubmed/28424065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3263-z
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