Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy

The tyrosine kinase encoded by the MET oncogene is activated by gene mutation or amplification in tumors, which in most instances maintain addiction, i.e., dependency, to MET activation. This makes MET an attractive candidate for targeted therapies. Here we show that, in 3/3 MET-addicted human gastr...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Musiani, Daniele, Konda, John David, Pavan, Simona, Torchiaro, Erica, Sassi, Francesco, Noghero, Alessio, Erriquez, Jessica, Perera, Timothy, Olivero, Martina, Di Renzo, Maria Flavia
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395734/
https://ncbi.nlm.nih.gov/pubmed/24903273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247924
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