The C677T variant in MTHFR modulates associations between brain integrity, mood, and cognitive functioning in old age

INTRODUCTION: The C677T functional variant in the methylene-tetrahydrofolate reductase (MTHFR) gene leads to reduced enzymatic activity and elevated blood levels of homocysteine. Hyperhomocysteinemia has been linked with higher rates of cardiovascular diseases, cognitive decline, and late-life depre...

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Veröffentlicht in:Biol Psychiatry Cogn Neurosci Neuroimaging
Hauptverfasser: Roussotte, Florence F., Hua, Xue, Narr, Katherine L., Small, Gary W., Thompson, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395287/
https://ncbi.nlm.nih.gov/pubmed/28435933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpsc.2016.09.005
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