GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome

Fragile X syndrome is a genetic condition resulting from FMR1 gene mutation that leads to intellectual disability, autism-like symptoms, and sensory hypersensitivity. Arbaclofen, a GABA-B agonist, has shown efficacy in some individuals with FXS but has become unavailable after unsuccessful clinical...

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Veröffentlicht in:eNeuro
Hauptverfasser: Sinclair, D., Featherstone, R., Naschek, M., Nam, J., Du, A., Wright, S., Pance, K., Melnychenko, O., Weger, R., Akuzawa, S., Matsumoto, M., Siegel, S. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2017
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New Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394929/
https://ncbi.nlm.nih.gov/pubmed/28451631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0380-16.2017
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