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Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?

For protection against pathogens, it is essential that naïve CD4(+) T cells differentiate into specific effector T helper (Th) cell subsets following activation by antigen presented by dendritic cells (DCs). Next to T cell receptor and cytokine signals, membrane-bound Notch ligands have an important...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tindemans, Irma, Peeters, Marlies J. W., Hendriks, Rudi W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394483/
https://ncbi.nlm.nih.gov/pubmed/28458667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00419
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