Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins i...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yuan, Yuan, Cao, Duanfang, Zhang, Yanfang, Ma, Jun, Qi, Jianxun, Wang, Qihui, Lu, Guangwen, Wu, Ying, Yan, Jinghua, Shi, Yi, Zhang, Xinzheng, Gao, George F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394239/
https://ncbi.nlm.nih.gov/pubmed/28393837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15092
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