A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

During development of the vertebrate central nervous system, the bHLH transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmental function is seen in human glioma wherein Olig2 is requ...

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Udgivet i:Cell Rep
Main Authors: Zhou, Jing, Tien, An-Chi, Alberta, John A., Ficarro, Scott B., Griveau, Amelie, Sun, Yu, Deshpande, Janhavee S., Card, Joseph D., Morgan-Smith, Meghan, Michowski, Wojciech, Hashizume, Rintaro, James, C. David, Ligon, Keith L., Snider, William D., Sicinski, Peter, Marto, Jarrod A., Rowitch, David H., Stiles, Charles D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394178/
https://ncbi.nlm.nih.gov/pubmed/28355568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.003
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