A Phase 2, Randomized, Placebo-Controlled, Dose-Ranging Study of the Calcium-Sensing Receptor Antagonist MK-5442 in the Treatment of Postmenopausal Women With Osteoporosis

CONTEXT: MK-5442 is an orally bioavailable calcium-sensing receptor antagonist that is hypothesized to stimulate bone formation by stimulating endogenous secretion of a pulse of PTH. Earlier clinical and preclinical studies demonstrated increased bone mineral density (BMD) after treatment. OBJECTIVE...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Halse, Johan, Greenspan, Susan, Cosman, Felicia, Ellis, Graham, Santora, Arthur, Leung, Albert, Heyden, Norman, Samanta, Suvajit, Doleckyj, Steven, Rosenberg, Elizabeth, Denker, Andrew E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393499/
https://ncbi.nlm.nih.gov/pubmed/25166719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-4009
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