Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent

[Image: see text] Photoremovable protecting groups added to bioactive molecules provide spatial and temporal control of the biological effects. We present synthesis and characterization of the first photoactivatable small-molecule tubulin inhibitor. By blocking the pharmacophoric OH group on compoun...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Döbber, Alexander, Phoa, Athena F., Abbassi, Ramzi H., Stringer, Brett W., Day, Bryan W., Johns, Terrance G., Abadleh, Mohammed, Peifer, Christian, Munoz, Lenka
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392771/
https://ncbi.nlm.nih.gov/pubmed/28435525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00483
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