Molecular Insights into Hydrogen Peroxide-sensing Mechanism of the Metalloregulator MntR in Controlling Bacterial Resistance to Oxidative Stresses

Manganese contributes to anti-oxidative stress particularly in catalase-devoid bacteria, and DtxR family metalloregulators, through sensing cellular Mn(2+) content, regulate its homeostasis. Here, we show that metalloregulator MntR (So-MntR) functions dually as Mn(2+) and H(2)O(2) sensors in mediati...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Chen, Zhaoyuan, Wang, Xinhui, Yang, Fan, Hu, Qingqing, Tong, Huichun, Dong, Xiuzhu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392694/
https://ncbi.nlm.nih.gov/pubmed/28223356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764126
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