AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: implications toward suppression of neointimal hyperplasia

Hypoadiponectinemia is associated with an increased risk of coronary artery disease. Although adiponectin replenishment mitigates neointimal hyperplasia and atherosclerosis in mouse models, adiponectin therapy has been hampered in a clinical setting due its large molecular size. Recent studies demon...

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Vydáno v:Pharmacol Res
Hlavní autoři: Fairaq, Arwa, Shawky, Noha M., Osman, Islam, Pichavaram, Prahalathan, Segar, Lakshman
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392421/
https://ncbi.nlm.nih.gov/pubmed/28237515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.02.016
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