Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alte...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Carbajosa, Sofía, Gea, Susana, Chillón-arinas, Carlos, Poveda, Cristina, Maza, María del Carmen, Fresno, Manuel, Gironès, Núria
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2017
Gaiak:
Research Paper: Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392268/
https://ncbi.nlm.nih.gov/pubmed/28147332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14886
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