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Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alte...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Carbajosa, Sofía, Gea, Susana, Chillón-arinas, Carlos, Poveda, Cristina, Maza, María del Carmen, Fresno, Manuel, Gironès, Núria
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392268/
https://ncbi.nlm.nih.gov/pubmed/28147332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14886
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