Characterization of H type 1 and type 1 N-acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4

Cancer-specific glycans of ovarian cancer are promising epitopes for targeting with monoclonal antibodies (mAb). Despite their potential, structural characterization of these glycan epitopes remains a significant challenge in mAb preclinical development. Our group generated the monoclonal antibody m...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Choo, Matthew, Tan, Heng Liang, Ding, Vanessa, Castangia, Roberto, Belgacem, Omar, Liau, Brian, Hartley-Tassell, Lauren, Haslam, Stuart M., Dell, Anne, Choo, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391748/
https://ncbi.nlm.nih.gov/pubmed/28167527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768887
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