Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of ‘neurometabolic’ integrity. One of the commonly accepted hallmarks of the aging process is thymic involution. At a relatively young age, 1...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Siddiqui, Sana, Lustig, Ana, Carter, Arnell, Sankar, Mathavi, Daimon, Caitlin M., Premont, Richard T., Etienne, Harmonie, van Gastel, Jaana, Azmi, Abdelkrim, Janssens, Jonathan, Becker, Kevin G., Zhang, Yongqing, Wood, William, Lehrmann, Elin, Martin, James G., Martin, Bronwen, Taub, Dennis D., Maudsley, Stuart
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391227/
https://ncbi.nlm.nih.gov/pubmed/28260693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101185
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