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Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals
BACKGROUND: G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) has been shown to participate in glucose homeostasis. In animal models, a TGR5 agonist increases incretin secretion to reduce hyperglycemia. Many agonists have been developed for clinical use. However, the effects of TGR...
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| Publicado no: | Drug Des Devel Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391213/ https://ncbi.nlm.nih.gov/pubmed/28435224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S131892 |
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