Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-b...

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Foilsithe in:eLife
Main Authors: Sundaramoorthy, Ramasubramanian, Hughes, Amanda L, Singh, Vijender, Wiechens, Nicola, Ryan, Daniel P, El-Mkami, Hassane, Petoukhov, Maxim, Svergun, Dmitri I, Treutlein, Barbara, Quack, Salina, Fischer, Monika, Michaelis, Jens, Böttcher, Bettina, Norman, David G, Owen-Hughes, Tom
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2017
Ábhair:
Biophysics and Structural Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391205/
https://ncbi.nlm.nih.gov/pubmed/28332978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22510
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