Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-b...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Sundaramoorthy, Ramasubramanian, Hughes, Amanda L, Singh, Vijender, Wiechens, Nicola, Ryan, Daniel P, El-Mkami, Hassane, Petoukhov, Maxim, Svergun, Dmitri I, Treutlein, Barbara, Quack, Salina, Fischer, Monika, Michaelis, Jens, Böttcher, Bettina, Norman, David G, Owen-Hughes, Tom
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Biophysics and Structural Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391205/
https://ncbi.nlm.nih.gov/pubmed/28332978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22510
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