Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-b...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sundaramoorthy, Ramasubramanian, Hughes, Amanda L, Singh, Vijender, Wiechens, Nicola, Ryan, Daniel P, El-Mkami, Hassane, Petoukhov, Maxim, Svergun, Dmitri I, Treutlein, Barbara, Quack, Salina, Fischer, Monika, Michaelis, Jens, Böttcher, Bettina, Norman, David G, Owen-Hughes, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391205/
https://ncbi.nlm.nih.gov/pubmed/28332978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22510
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