Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy

Macroautophagy allows for bulk degradation of cytosolic components in lysosomes. Overexpression of GFP/RFP‐LC3/GABARAP is commonly used to monitor autophagosomes, a hallmark of autophagy, despite artifacts related to their overexpression. Here, we developed new sensors that detect endogenous LC3/GAB...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Lee, You‐Kyung, Jun, Yong‐Woo, Choi, Ha‐Eun, Huh, Yang Hoon, Kaang, Bong‐Kiun, Jang, Deok‐Jin, Lee, Jin‐A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391143/
https://ncbi.nlm.nih.gov/pubmed/28320742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696315
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