Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis?

BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is one of the major risks of natalizumab therapy. Despite introduction of the currently employed PML risk stratification algorithm, the incidence of natalizumab-associated PML cases is not decreasing. OBJECTIVES: We addressed the following...

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Udgivet i:PLoS One
Main Authors: Krämer, Julia, Tenberge, Jan-Gerd, Kleiter, Ingo, Gaissmaier, Wolfgang, Ruck, Tobias, Heesen, Christoph, Meuth, Sven G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391008/
https://ncbi.nlm.nih.gov/pubmed/28406921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174858
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