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Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor

The incorporation of fluorine atoms into functional molecules is of wide interest in synthetic organic chemistry as well as cognate disciplines. In particular, in medicinal chemistry, there is a strong desire to positively influence the physicochemical molecular properties of drug compounds by intro...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Fischer, Thomas, Riedl, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390795/
https://ncbi.nlm.nih.gov/pubmed/28413749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201600158
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