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Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Oct4A is a master regulator of self-renewal and pluripotency in embryonic stem cells. It is a well-established marker for cancer stem cell (CSC) in malignancies. Recently, using a loss of function studies, we have demonstrated key roles for Oct4A in tumor cell survival, metastasis and chemoresistanc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Samardzija, Chantel, Greening, David W., Escalona, Ruth, Chen, Maoshan, Bilandzic, Maree, Luwor, Rodney, Kannourakis, George, Findlay, Jock K., Ahmed, Nuzhat
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390261/
https://ncbi.nlm.nih.gov/pubmed/28406185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46312
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