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Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment
Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer’s disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in transgenic mouse models that express the P301L tau mutation...
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| Pubblicato in: | Acta Neuropathol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Berlin Heidelberg
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389999/ https://ncbi.nlm.nih.gov/pubmed/28091722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1674-1 |
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