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ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization
Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor suppressor ING1b binds rDNA, regulates rDNA chromatin modifications and affects nucleolar localization of mTOR to modulate rRNA levels. ING1 represses rDNA...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389678/ https://ncbi.nlm.nih.gov/pubmed/27903908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1161 |
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