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ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization
Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor suppressor ING1b binds rDNA, regulates rDNA chromatin modifications and affects nucleolar localization of mTOR to modulate rRNA levels. ING1 represses rDNA...
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| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389678/ https://ncbi.nlm.nih.gov/pubmed/27903908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1161 |
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